Anitis and proctitis are frequent proctological disease whose cause is always unknown. The main treatment of these conditions is medical using local antinflammatory and phlebotonic drugs. The aim of the present study was to evaluate the effect on symptoms relief using the association of local mesalazine and bergamot-derived gel (Benebeo gel®) in patients with anitis and or proctitis. From January 2016 to January 2018, a total of 278 patients were treated with the association of local mesalazine and Benebeo gel® with good symptoms relief and improvement of local conditions at 1 months and maintained also at three months. The complementary effects of local antiflammatory and bergamot-derived flavonoids lead to a good and prolonged clinical response with optimal satisfaction of the patients. Further studies are needed to confirm these preliminary results.